Completeness beginning insulin absorption and the effect depends on the site of injection (abdomen, thigh, buttocks), the dose (amount of injected insulin), insulin concentration in the formulation, etc., unevenly distributed in the body; It does not cross the placental barrier low t treatment and into breast milk. It destroyed insulinase mainly in the liver and kidneys. Excreted by the kidneys (30-80%).
- Diabetes, require insulin therapy.
- Pregnancy in patients with diabetes mellitus.Contraindications
- Increased sensitivity to insulin or to one component of the drug.
- Hypoglycemia.Use during pregnancy and lactation
During pregnancy, especially important to maintain good control in patients receiving insulin therapy (with insulin-dependent diabetes or gestational diabetes). The need for insulin usually decreases during the I trimester and increase during the II and III trimester. During birth and immediately after their need for insulin can dramatically decrease. Patients with diabetes are advised to inform the physician about pregnancy or planning pregnancy. In patients with diabetes during lactation may require dose adjustment of insulin, diet, or both.Dosing and Administration
Dose low t treatment determined by the physician individually depending on the blood glucose level. The drug should be administered subcutaneously. Perhaps, and intramuscular administration.
Intravenous NPH is contraindicated.
The temperature of the injectable preparation must comply room. Subcutaneous injections should be done in the shoulder area, thighs, buttocks or abdomen. Injection sites must be alternated so that the same site was used no more than approximately once a month. When insulin administered subcutaneously care should be taken not to fall into a blood vessel at the injection. After injection, do not massage the injection site. Patients should be trained in the proper use of the device for administering insulin. Insulin injection mode individually.
Preparations for the introduction of
Just prior to use cartridges low t treatment should be rolled between your hands ten times and shake, turning 180 ° and up to ten times the total resuspend insulin until it takes the form of a homogeneous turbid liquids or milk. Do not shake vigorously as this may result in foam that can prevent proper set dose. Inside each cartridge is a small glass bead to facilitate mixing insulin. Do not use insulin if it has flakes after mixing.
The device does not allow the cartridge to mix their contents with other insulin directly into the cartridge. Cartridges are not designed to be refilled.
Before the injection should be familiar with the manufacturer’s instructions on the use of pen-injector for administering insulin.
Side effects Hypoglycemia is the most common side effects of the introduction of insulin preparations, includingH. Severe hypoglycemia may lead to unconsciousness and, in extreme cases, death. Allergic reactions: patients may experience local allergic reactions such as redness, swelling or itching at the injection site. These reactions usually disappear over a period of several days to several weeks. In some cases, these reactions may be caused by factors not related to the insulin, such as skin irritation or wrong cleaning agent for injection. Systemic allergic reactions caused by insulin occur less frequently, but are more serious. They can manifest themselves with generalized itching, difficulty breathing, shortness of breath, decreased blood pressure, increased heart rate, increased sweating.Severe cases of systemic allergic reactions may be life threatening. In rare cases, severe allergy to low t treatmentimmediate holding of NPH treatment is required. You may need a change of insulin or desensitisation holding. With prolonged use – may develop lipodystrophy at the injection site.