Treatment: removal of preparation, if necessary – hospitalization, the appointment of symptomatic treatment for the correction of water-salt balance, hemostasis disorders and other disorders.. . See “Important information”.
No cases of overdose for other indications have not been observed.
Long-term use of the drug testim gel is not recommended due to the possible formation of antibodies reduce the effectiveness of treatment. Men is not effective at high levels of follicle stimulating hormone . In women before prescribing the should be evaluated follicular growth and cervical index (for two days prior to the effect of the stimulation). In the process of stimulation – ultrasonography and monitoring of plasma estradiol concentrations should be performed daily. Ovarian reaction can also be assessed using cervical index. In the application of gonadotropin preparations may develop syndrome. Syndrome OHSS 1st degree does not require treatment, accompanied by a slight increase in the size of the ovaries (5-7 cm), the high concentration of sex steroids and pain abdomen. The patient should be informed about her condition and carefully monitored. Syndrome testim gel2nd degree requires hospitalization and symptomatic treatment including intravenous infusion solutions for maintaining bcc (in case of increase in hemoglobin concentration). Ovarian cysts the size of 8-10 cm are accompanied by abdominal symptoms, nausea and vomiting. For syndrome OHSS grade 3 ovarian cysts characteristic size of 10 cm or more, ascites, hydrothorax, and an increase in abdominal pain, shortness of breath, a violation of water-electrolyte balance blood and increase its viscosity, accompanied by increased platelet adhesion to the risk of thromboembolic complications. Hospitalization is required. In the case of the syndrome treatment with should be discontinued. In the case of pregnancy symptoms of syndrome may be increased. In pregnancy arising after the induction of ovulation, gonadotropic drugs increases the risk of multiple pregnancies and, consequently, the risk to the mother (morbidity pregnancy and birth) and neonatal (low body weight).
Also, women with infertility, which offered treatment methods of reproductive technologies (especially in vitro fertilization), common pathology of the fallopian tubes, which can lead to an increased risk of ectopic pregnancy, in connection with which, in the early stages of pregnancy should be carried ultrasound for further localization ovum. during treatment testim gel and within 10 days after discontinuation of treatment, it can affect the value of immunologic tests for in the blood plasma / urine, which can lead to a false positive pregnancy test. pregnancy and the period breastfeeding is not used during normal pregnancy and breastfeeding. The drug has no negative impact on the ability to drive vehicles and other mechanisms.
Side effects: Local reactions: pain at the injection site, flushing, headache, fatigue, irritability, anxiety, depression; allergic reactions (fever, skin rash, angioedema); suppression of gonadotropic pituitary function. The women in the combined treatment of infertility (in conjunction with menotropinami or clomiphene) – OHSS syndrome (large ovarian cysts (prone to rupture), hemoperitoneum, hydrothorax, ascites, weight gain, edema, dizziness, breast tenderness, oliguria, increased blood viscosity, in rare cases – thromboembolic complications. The men – swelling, hypersensitivity nipple breast, gynecomastia, testicular enlargement in the inguinal canal (with cryptorchidism), prostatic hyperplasia, acne vulgaris, penis enlargement, premature puberty . If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, inform your doctor.
Interaction with other drugs testim gel should not be mixed with other drugs! Avoid joint use of the with high doses of corticosteroids.